Open Access Highly Accessed Research article

Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats

Ernesto A Aguilar Salegio, Anthony N Pollard, Malcolm Smith and Xin-Fu Zhou*

Author Affiliations

Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide 5001, Australia

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BMC Neuroscience 2011, 12:11  doi:10.1186/1471-2202-12-11

Published: 20 January 2011

Additional files

Additional file 1:

Glial Scar Formation at Spinal Cord Injury Epicentre. Montage of the spinal cord lesion epicentre demonstrating the extent of glial scar formation after the injury to the dorsal columns. Immunoreactive GFAP+ staining identifies the location of lesion epicentre (yellow asterisk), validates the paradigm for astrocyte quantification and delineates the presence of the physical/biochemical barrier against axonal regeneration in the matured CNS (dashed line). Scale bars montage 500 μm.

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