Table 1

Comparison of Casp3 mutant mice

Casp3 KO mice

Casp3 KO mice

Melody ENU mutant

Casp3ex3KO mice

(Takahashi et al., 2001[7])

(Morishita et al., 2001[8])

(Parker et al., 2010[9])

(This study)


Targeted deletion

QACRG catalytic domain

QACRG catalytic domain

QACRG catalytic domain

Exon 3

or mutation site

Exons 5-6

Exons 5-6

C163S point mutation

Phenotype

Survive on C57BL/6 background

Survive on C57BL/6 background

C3H background

Survive on C57BL/6 background

Smaller body size

Smaller body size

Smaller body size

Smaller body size

Progressive hearing loss

Progressive hearing loss

Hearing loss

Hearing loss

Hyperactive

Hyperactive

Circling behavior

Circling behavior

Cochlear histology

Hyperplasia of border cells

Loss of cochlear hair cells

Loss of cochlear hair cells

Loss of cochlear hair cells

Degeneration of cochlear hair cells, spiral ganglion cells

Loss of spiral ganglion cells

Loss of spiral ganglion cells


KO, knockout. ENU, N-ethyl-N-nitrosourea.

Makishima et al. BMC Neuroscience 2011 12:102   doi:10.1186/1471-2202-12-102

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