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This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Poster Presentation

An interlocked oscillator model for firing of the mesencephalic dopaminergic neuron.

Joon Ha* and Alexey Kuznetsov

Author Affiliations

Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, Indianapolis, IN, 46202 USA

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BMC Neuroscience 2010, 11(Suppl 1):P151  doi:10.1186/1471-2202-11-S1-P151


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/11/S1/P151


Published:20 July 2010

© 2010 Ha and Kuznetsov; licensee BioMed Central Ltd.

Poster Presentation

Dopaminergic (DA) neurons display two functionally distinct modes of electrical activity: low- and high-frequency firing. We suggest a new minimal computational model that unites data on these firing modes obtained under different experimental conditions. The model reproduces the separation of maximal frequencies under NMDA synaptic stimulation vs. other treatments. In accord to recent experimental data, NMDA stimulation restricted to the soma effectively evokes high-frequency oscillations in the model. We have also reproduced low- and high-frequency oscillations under blockade of the SK current. Thus, the new model suggests a way that overcomes all major limitations of the switching dominance mechanism for controlling the frequency of the DA neuron. We explain recent experimental facts and make further predictions.