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This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Poster Presentation

Learning mechanisms for DA-modulated spiking networks in the basal ganglia

Simon M Vogt* and Ulrich G Hofmann

Author Affiliations

Institute for Signal Processing, University of Lübeck, Lübeck, 23538, Germany

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BMC Neuroscience 2010, 11(Suppl 1):P106  doi:10.1186/1471-2202-11-S1-P106

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/11/S1/P106


Published:20 July 2010

© 2010 Vogt and Hofmann; licensee BioMed Central Ltd.

Poster Presentation

How the basal ganglia act to gate cortically planned actions is a topic of current discussion. Interesting work by Gurney et al [1-3] suggests an interaction between the STN and GPe as a central element of inhibition for action gating, with pathological oscillations occurring if striatal input changes due to dopamine depletion in Parkinson's disease.

But what exactly changes in the signals that the striatum projects to the rest of the basal ganglia? How could the altered dopamine signal and its effect on striatal learning influence the observed functions of the basal ganglia in Parkinsonian and in healthy patients?

While rate-based learning models of the basal ganglia have been suggested [5], a spiking network that reproduces basal ganglia anatomy and autonomously learns a set of possible action sequences that can then be reinforced through dopamine feedback has yet to be demonstrated.

On the way to constructing such a network, we present some effects of spike timing dependent plasticity, synaptic delay, group inhibition, noisy & localised projections and dopamine modulation on feed-forward and associative spiking networks within the basal ganglia and cortex.

References

  1. Gurney K, Prescott TJ, Redgrave P: A computational model of action selection in the basal ganglia. I. A new functional anatomy.

    Biol. Cybern 2001, 84:401-410. PubMed Abstract | Publisher Full Text OpenURL

  2. Humphries MD, Stewart RD, Gurney KN: A physiologically plausible model of action selection and oscillatory activity in the basal ganglia.

    J Neurosci 2006, 26:12921-42. PubMed Abstract | Publisher Full Text OpenURL

  3. Bogacz R, Gurney K: The basal ganglia and cortex implement optimal decision making between alternative actions.

    Neural Comput 2007, 19:442-477. PubMed Abstract | Publisher Full Text OpenURL

  4. Cisek P: Cortical mechanisms of action selection: the affordance competition hypothesis.

    Philos Trans R Soc Lond B Biol Sci 2007, 362:1585-1599. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  5. Frank MJ: Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism.

    J Cogn Neurosci 2005, 17:51-72. PubMed Abstract | Publisher Full Text OpenURL

  6. Schultz W: Multiple reward signals in the brain.

    Nature Reviews Neuroscience 2000, 1:199-207. PubMed Abstract | Publisher Full Text OpenURL

  7. Farries MA, Fairhall AL: Reinforcement learning with modulated spike timing dependent synaptic plasticity.

    Journal of neurophysiology 2007, 98:3648-65. PubMed Abstract | Publisher Full Text OpenURL

  8. Masquelier T, Guyonneau R, Thorpe SJ: Competitive STDP-based spike pattern learning.

    Neural Computation 2009, 21:1259-76. PubMed Abstract | Publisher Full Text OpenURL

  9. Potjans W, Morrison A, Diesmann M: A spiking neural network model of an actor-critic learning agent.

    Neural computation 2009, 21:301-39. PubMed Abstract | Publisher Full Text OpenURL

  10. Singh SP, Barto AG, Chenanez N: Intrinsically motivated reinforcement learning.

    Advances in Neural Information Processing Systems 2005, 17:1281-1288. OpenURL