Email updates

Keep up to date with the latest news and content from BMC Neuroscience and BioMed Central.

This article is part of the supplement: Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Open Access Oral presentation

Feedback control of the spatiotemporal firing pattern of a basal ganglia microcircuit model

Jianbo Liu1*, Karim G Oweiss12 and Hassan K Khalil1

Author Affiliations

1 Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan, USA

2 Neuroscience Program, Michigan State University, East Lansing, Michigan, USA

For all author emails, please log on.

BMC Neuroscience 2010, 11(Suppl 1):O16  doi:10.1186/1471-2202-11-S1-O16

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/11/S1/O16


Published:20 July 2010

© 2010 Liu et al; licensee BioMed Central Ltd.

Oral presentation

One of the fundamental objectives in systems neuroscience is to precisely control the spatiotemporal firing patterns of cortical neurons to elicit a desired pattern of activity. In this work, we study the effects of intracortical micro-stimulation on the dynamics of a basal ganglia microcircuit model, and explore the feasibility of controlling the spatiotemporal firing patterns of the modeled population in the presence of unobserved inputs. Results from the simulation study suggest that properly designed Multiple-Input-Multiple-Output (MIMO) feedback control paradigm can force a subpopulation of observed output neurons to follow a prescribed spatiotemporal firing pattern despite the presence of unobserved inputs. The accuracy of the spike timing of the controlled neural firing with respect to the reference spike trains is in the order of tens of milliseconds.