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Open Access Research article

Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI

Xing'an Li12, Yingjiu Zhang2, Peng Xie3, Jinhua Piao4, Yihong Hu1, Ming Chang1, Tao Liu5 and Linsen Hu1*

Author Affiliations

1 Department of Neurology, The First Affiliated Hospital, Jilin University, Changchun 130021, China

2 Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education (Jilin University), Changchun 130021, China

3 Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

4 Department of Cardiovascular Pediatrics, The First Affiliated Hospital, Jilin University, Changchun 130021, China

5 College of Life Sciences, Jilin University, Changchun 130021, China

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BMC Neuroscience 2010, 11:95  doi:10.1186/1471-2202-11-95

Published: 12 August 2010

Additional files

Additional file 1:

A list of proteins identified from an isolated fraction of PSI-induced inclusions in PC12 cells by MALDI-TOF MS PMF. MS data were specifically searched for proteins by proteomic analysis.

Format: DOC Size: 180KB Download file

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Open Data

Additional file 2:

MS spectra of the unknown proteins of interest. The eight proteins were incompletely determined by the Profound search engine using the single NCBInr database alone.

Format: RAR Size: 623KB Download file

Open Data

Additional file 3:

A list of the identified chaperone proteins with both putative similarities between protein families and predictable resources for subcellular localization. A portion of seventeen chaperone proteins have been found in available literatures to share some similarity between protein families and to specialize in various cellular localization resources.

Format: DOC Size: 48KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data