Open Access Highly Accessed Research article

Automated quantitative gait analysis in animal models of movement disorders

Caroline Vandeputte12, Jean-Marc Taymans2, Cindy Casteels1, Frea Coun2, Yicheng Ni3, Koen Van Laere1 and Veerle Baekelandt2*

Author Affiliations

1 Division of Nuclear Medicine, K.U. Leuven, Leuven, Belgium

2 Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, K.U. Leuven, Belgium

3 Department of Radiology, K.U. Leuven, Leuven, Belgium

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BMC Neuroscience 2010, 11:92  doi:10.1186/1471-2202-11-92

Published: 9 August 2010

Additional files

Additional file 1:

Locomotor velocities for each experimental group. Velocities are expressed as centimeters traveled per second. Results of statistical comparisons between model animals and respective control animals are given in column 4.

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Additional file 2:

Shows the results of the Rotarod test performed on tgHD (A) and photothrombotic stroke rats (B) compared to control animals. Experimental groups were prepared and submitted to rotarod analysis as described in Methods. Shown are latency to fall off the rotarod at different rotation speeds (8-16 rpm) using a session time of 120 seconds. Data are shown as mean ± s.e.m., In B none of the control animals fell during the imparted session time.

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Additional file 3:

Catwalk automated gait analysis test of tgHD and littermate control rats at three and four months of age. (A and B) Show the duration of paw contact of all limbs for tgHD (light) and control rats (dark). (C and D) represent the swing speed of the same animals.

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