Figure 1.

Three-generation breeding scheme for chemically-induced mutant fish. Male fish are mutagenised and then crossed to wild-type females to produce an F1 generation. An F2 generation is made by in-crossing F1 siblings. Dominant behavioural mutants can be identified in this F2 generation (black fish). For recessive mutant carriers, a second in-cross is performed and the progeny screened for behavioural alterations (red fish) - if the inheritance in Mendelian then one quarter of the progeny should show the behavioural defect.

Norton and Bally-Cuif BMC Neuroscience 2010 11:90   doi:10.1186/1471-2202-11-90
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