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Adult zebrafish as a model organism for behavioural genetics

William Norton and Laure Bally-Cuif

Author affiliations

Zebrafish Neurogenetics group, Laboratory of Neurobiology & Development (NED), CNRS, UPR 3294, Institute of Neurobiology Albert Fessard, Avenue de la Terrasse, 91198 cedex, Gif-sur-Yvette, France

Citation and License

BMC Neuroscience 2010, 11:90  doi:10.1186/1471-2202-11-90

Published: 2 August 2010


Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular analysis of zebrafish behavioural mutants is now starting, allowing the identification of novel behavioural control genes. As a result of this, studies of adult zebrafish are now helping to uncover the genetic pathways and neural circuits that control vertebrate behaviour.