Table 1

Curcumin neutralizes αS-induced cytotoxicity in SH-SY5Y cells

Sample

LDH (% control)

SE

p-value

Viability (% control)

SE

p-value


Tris buffer (control)

100

2.4

NA

100

4.3

NA

αS

121.5

3.5

0.005a

67.9

1.9

0.004a

αS + curcumin

99.7

5.3

0.018b

89.1

4.1

0.008b

Curcumin

99.3

4.9

0.936

96.8

5.6

0.501


Cytotoxicity was measured using LDH assay and cell viability was determined using resazurin reduction assay. SH-SY5Y cells were incubated with Tris buffer (control), αS, αS+curcumin and curcumin for 48 hr before analysis. The LDH release and cell viability were expressed as a percentage of the untreated samples. Data was reported as mean ± SE, n = 4. acompared with the control; bcompared with αS-treated samples.

Wang et al. BMC Neuroscience 2010 11:57   doi:10.1186/1471-2202-11-57

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