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Open Access Highly Accessed Research article

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

Min S Wang12, Shanta Boddapati1, Sharareh Emadi1 and Michael R Sierks1*

Author Affiliations

1 Department of Chemical Engineering, Arizona State University, Tempe, AZ 85287-6006 USA

2 Department of Chemistry, University of Colorado Denver, Denver, CO 80217-3364 USA

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BMC Neuroscience 2010, 11:57  doi:10.1186/1471-2202-11-57

Published: 30 April 2010

Additional files

Additional file 1:

Curcumin alters αS aggregation kinetics. Aggregation kinetics were monitored using Thioflavin T assay. (A) monomeric αS and monomeric αS + curcumin, (B) pre-formed oligomeric αS and pre-formed oligomeric αS + curcumin, (C) pre-formed fibrillar αS and pre-formed fibrillar αS + curcumin. Samples were taken at the indicated time and mixed with Thioflavin T. The observed Thioflavin T fluorescence (Ex = 450 nm, Em = 482 nm) was normalized to each untreated αS sample at its maximum value. Data are presented as mean ± SE from 4 sets of experiments.

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