Table 2

Preservation of GSH stores by pantethine treatment.

Days following 2'-methyl-MPTP injection


Day 1

Day 7


Control

2.00 ± 0.13

1.81 ± 0.09

2'-methyl-MPTP + saline

1.25 ± 0.18

1.66 ± 0.20

2'-methyl-MPTP + pantethine

1.96 ± 0.12§

1.79 ± 0.10

Control + pantethine

2.54 ± 0.29#


Total brain glutathione levels were determined in 2'-methyl-MPTP- intoxicated mice, treated with either saline or pantethine. Glutathione levels are expressed as μmol/g of tissue. Values are means ± SD; n = 6 mice per assay. Significant increase versus paired saline, § p < 0.05, and versus the control group, #p < 0.05.

Cornille et al. BMC Neuroscience 2010 11:51   doi:10.1186/1471-2202-11-51

Open Data