In vitro improvement of mitochondrial functions by pantetheine. Mitochondria were isolated from control mice and incubated with increasing concentrations of MPP+ for 5 min; 0, 0.5 or 1 mM pantetheine was then added and (A) complex I activity, (B) oxygen consumption and (C) ATP levels were determined. Values are means ± SD; n = 4 mice per assay. Significant difference between assays in the presence of the absence of pantetheine, **p < 0.01.
Cornille et al. BMC Neuroscience 2010 11:51 doi:10.1186/1471-2202-11-51