Preservation of mitochondrial complex I activity by pantethine treatment. Mitochondria were isolated from saline or pantethine-treated mice and incubated with 0, 1.25, 2.5 and 5 mM of MPP+ for 5 min, then complex I activity was determined. Values are means ± SD; n = 4 mice per assay. Significant difference between pantethine-treated versus saline groups, **p < 0.01.
Cornille et al. BMC Neuroscience 2010 11:51 doi:10.1186/1471-2202-11-51