Iodine deficiency and hypothyroidism down-regulated doublecortin in hippocampal subregions. ID, iodine-deficient group. The upper bands (A) depict representative findings for rats subjected to developmental iodine deficiency and PTU-induced hypothyroidisms. The lower bar graphs show the results of the semi-quantitative measurement of doublecortin following developmental iodine deficiency and PTU-induced hypothyroidisms, for the CA1 (B), CA3 (C), and DG (D) regions. The height of each bar represents the mean ± SD for the groups. Within each time point, * indicates a significant difference from the control group, p < 0.05 (n = 3).
Gong et al. BMC Neuroscience 2010 11:50 doi:10.1186/1471-2202-11-50