Iodine deficiency and hypothyroidism damaged nerve fibers in DG region. ID: Iodine-deficient group. On PN14 and PN21, cell bodies were arranged in order in each group, and fewer nerve fibers were observed. No markedly differences were observed between the control and the treatment groups (n = 5). On PN28 and PN42, silver-stained fibers (labeled with arrows) degeneration became apparent. Nerve fibers in iodine-deficient (Figure 3j&3n), 5 ppm PTU-treated (Figure 3k&3o), and 15 ppm PTU-treated (Figure 3l&3p) groups were arranged in disorder or disrupted, while nerve fibers in the controls (Figure 3i&3m) were arranged in order and distinct. Fewer nerve fibers were observed in the treatment groups than the controls. Scale bar represents 10 μm at lower left in (a) and applies to all panels.
Gong et al. BMC Neuroscience 2010 11:50 doi:10.1186/1471-2202-11-50