Iodine deficiency and hypothyroidism impaired nerve fibers in CA3 region. ID: Iodine-deficient group. On PN14 and PN21, cell bodies were arranged in order in each group, and fewer nerve fibers were observed. No markedly differences were observed between the control and the treatment groups (n = 5). On PN28 and PN42, nerve fibers (labeled with arrows) degeneration was obvious to identify between the groups. In iodine-deficient (Figure 2j&2n), 5 ppm PTU-treated (Figure 2k&2o), and 15 ppm PTU-treated (Figure 2l&2p) groups, nerve fibers were arranged in disorder, distorted, or disrupted, and some of them were concentrated and fused, while in the controls (Figure 2i&2m) were arranged in order and distinct. Scale bar represents 10 μm at lower left in (a) and applies to all panels.
Gong et al. BMC Neuroscience 2010 11:50 doi:10.1186/1471-2202-11-50