The mapping in knock-ins obtained by the computational model. The complete map structure is color-coded according to the axonal origin in retina as shown by the left column. In addition, the termination zones for a small subset of axons indicated by the red points are shown for temporal (upper row), central (center row) and nasal (lower row) labelings. This is to model the results of anterograde labeling as in Figure 3. The heterozygous knock-ins (central column) have smaller levels of the additional EphA receptor than homozygotes (right column). Comparison with experimental results in Figure 3 shows similarity. The maps in the central and right columns show the results of 6 simulations with different random initial connectivities. These panels show variability in projections, especially obvious in the heterozygous case (central column). The variability is mostly confined to the interface between wt and ki branches of the map, with the occasional formation of small folds (bottom panel).
Tsigankov and Koulakov BMC Neuroscience 2010 11:155 doi:10.1186/1471-2202-11-155