Ipsilateral ischemic hemispheric BWC. BWC(%) in the ipsilateral ischemic hemisphere of the normal saline group, 20% mannitol group and 10% HS group at 2, 6, 12 and 18 h following permanent MCAO and the corresponding sham operated group. Bar graph shows that the percentage of BWC is significantly increased in the ipsilateral ischemic hemisphere of the normal saline group, 20% mannitol group and 10% HS group at various time points when compared with the sham operated group (*#&P < 0.05). The percentage of BWC decreases significantly in the ipsilateral ischemic hemisphere at 2, 6 and 12 h following treatment with 20% mannitol or 10% HS compared with the normal saline group (#P < 0.05, ※P < 0.05). At 18 h, compared with the normal saline group, the percentage of BWC in the 20% mannitol does not decrease significantly (&P > 0.05). However, the BWC of 10% HS group continues to decrease significantly (※P < 0.05). BWC in the ipsilateral ischemic hemispheres of the 10% HS group at 2, 6, 12 and18 h decreases significantly when compared with the 20% mannitol group(※P < 0.001).
Zeng et al. BMC Neuroscience 2010 11:153 doi:10.1186/1471-2202-11-153