Table 4

Phenotypic Differences Between Thoracic and Cervical Propriospinal Neurons

Fold Chg

Individual Fold Chg

Post hoc P value

Gene

Level F

Level P

FDR

ΔΔCp

Cerv-Thor

Time1

Time2

Time3

Time1

Time2

Time3


Hspb1

159.50

0.00002

0.001

-3.67

12.8

0.9

43.2

50.9

0.9273

0.0426

0.0833

Lifr

142.15

0.00002

0.001

-3.31

9.9

7.2

6.3

21.7

0.062

0.0273

0.0029

Ldha

104.55

0.00005

0.001

3.06

0.1

0.1

0.2

0.1

2E-05

0.0003

0.0062

Rplp1

82.46

0.00010

0.001

-3.55

11.7

10.2

8.9

17.7

6E-06

0.0004

0.0001

Nf1

53.07

0.00030

0.004

-2.29

4.9

1.4

4.0

20.6

0.7123

0.0375

0.0509

Ntf5

52.54

0.00040

0.004

-5.52

46.0

14.5

48.6

138.2

0.0027

0.0139

0.0107

Crhr1

34.54

0.00110

0.009

-5.69

51.5

7.8

88.0

198.9

0.0633

0.0091

0.0073

Gfra2

34.36

0.00110

0.008

-2.54

5.8

1.2

8.8

18.4

0.6241

0.1267

0.0388

Gfra1

26.31

0.00220

0.014

-3.29

9.8

3.8

12.1

20.5

0.3976

0.0122

0.002

HcRt

20.89

0.00380

0.022

-7.96

248.3

29.1

857.7

614.3

0.0049

0.0159

0.0079

Ntrk2

19.49

0.00450

0.024

-0.22

1.2

0.7

1.1

2.2

0.5642

0.9113

0.5394

Zfp110

19.21

0.00470

0.023

-2.74

6.7

2.9

8.5

12.3

0.2716

0.0457

0.1485

Tp53

17.61

0.00570

0.026

-2.49

5.6

5.1

5.5

6.3

0.1686

0.0759

0.1054

Tgfa

16.48

0.00670

0.028

-3.99

15.9

3.5

21.7

53.0

0.0804

0.0008

0.0015

Ntrk1

14.67

0.00870

0.034

-5.98

63.3

19.7

106.5

120.6

0.0049

0.0006

0.0006

Zfp91

14.44

0.00900

0.033

-1.70

3.2

1.4

3.0

8.0

0.5574

0.252

0.0011

Npffr2

13.86

0.00980

0.034

-4.59

24.1

9.3

19.3

78.0

0.0283

0.0038

0.0007

Artn

13.89

0.00980

0.032

-6.97

125.4

21.8

335.2

270.2

0.0017

0.0482

0.0045

Npy1r

13.61

0.01020

0.032

-5.44

43.3

4.9

89.2

184.5

0.1173

0.0017

0.0002

Fgfr1

12.28

0.01280

0.038

-1.33

2.5

1.6

3.4

3.0

0.3199

0.0554

0.1921

Stat1

11.92

0.01360

0.038

-0.54

1.5

0.2

8.0

1.9

0.2964

0.0022

0.7465

Fus

10.51

0.01760

0.047

-1.56

3.0

1.7

2.0

7.3

0.066

0.1028

0.0051

Cntfr

10.26

0.01850

0.047

-0.52

1.4

1.6

0.9

2.2

0.5502

0.8505

0.4669

Npy

10.16

0.01890

0.046

-1.45

2.7

0.9

2.9

8.2

0.8662

0.0062

0.0459

Frs2

9.82

0.02020

0.048

-1.22

2.3

0.8

3.4

4.8

0.8758

0.0124

0.3093

Adcyap1r1

9.22

0.02290

0.052

-4.42

21.5

9.0

27.6

39.9

0.0268

0.0043

9E-05

Hprt

9.22

0.02290

0.050

2.19

0.2

0.2

0.2

0.3

0.0719

0.0575

0.002

Ppyr1

7.79

0.03150

0.066

-6.86

116.2

31.2

69.5

723.5

0.1673

0.0261

0.0019

Tgfb1

7.65

0.03260

0.066

-3.84

14.3

13.9

7.9

26.9

0.0056

0.0095

0.0071

Mt3

6.94

0.03880

0.076

0.14

0.9

0.9

0.9

0.9

0.7328

0.4609

0.8946

Rpl13a

6.27

0.04630

0.088

-1.66

3.2

4.4

3.1

2.3

0.0223

0.0435

0.0002


Phenotypic differences between Thoracic and Cervical Propriospinal neurons. Significant differences in gene expression between LDPT and TPS neurons were detected using a 2 way ANOVA (shown in bold at Time 1, 1-week; Time 2, 2-weeks; and Time 3, 4-weeks post-FG injection). Genes were analyzed for a significant effect of level. P-values were then corrected for multiple testing, by applying the Benjamini-Hochberg FDR algorithm. A Welch's t-test, was used to determine at which specific time-point the difference in gene expression was significant. In the table above 2E-05 represents P values of 2 × 10-5 and 2 E-06 represents a P value of 2 × 10-6. Significant post-hoc P values are shown in italics.

Siebert et al. BMC Neuroscience 2010 11:148   doi:10.1186/1471-2202-11-148

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