Increased hyperphosphorylation of tau after rotenone exposure. Photomicrographs illustrating the immunoreactivity of hyperphosphorylated tau in cultured cells of hipoccampus exposed to DMSO (A) or 0.5 nM of rotenone (B) for 48 hours. Arrows indicate sites of hyperphosphorylated tau, possibly aggregated, distributed throughout cytoplasm and neurites. Scale bar = 50 μm.
Chaves et al. BMC Neuroscience 2010 11:144 doi:10.1186/1471-2202-11-144