Outline of screening tiers. Aβ40 in four brain samples (sagittal left halves) from 1930 different mouse KO strains were determined. Of these, 77 KO strains were selected for further Aβ40 determinations, and in some cases Aβ42 determinations, of the corresponding right brain halves. The gene information for four of the KO strains is reported in the current study. Prioritization for possible drug discovery efforts was then based upon multiple considerations, including the robustness of Aβ inhibition, tractability of the target for small molecule inhibition, and relevance of the target to AD.
Toyn et al. BMC Neuroscience 2010 11:143 doi:10.1186/1471-2202-11-143