Signal characteristics of neocortical local field potentials. A, top view (schematic) of a rat cortical hemisphere and approximate location of the recording electrode array in one animal (rat1). The electrodes were arranged in two rows and placed in the primary somatosensory (barrel) cortex, parallel to the rostrocaudal axis (sizes are not to scale). Gray dots correspond to dysfunctional electrodes. Due to the curvature of the neocortex electrode row 2 was in a deeper cortical lamina as compared to row 1. B, exemplary raw local field potential excerpts of 2 s length, filtered between 0.5 and 200 Hz, from the same animal at control, at a sedating concentration and an anesthetic concentration of isoflurane and after recovery. Note the similarity of the signals within each row (electrodes 1-7 and 9-14) and particularly between adjacent pairs of electrodes. C, power spectral density (PSD) plots of all raw data segments selected for analysis (channel 1 only). The insets depict the PSD in the range 40-200 Hz in double logarithmic coordinates. For comparison, the PSD under control conditions is replotted in gray in the background. D, Cross correlation of the same data as depicted in C. Each grayscale-coded matrix contains values obtained from non-redundant pairwise combinations of recording sites (except auto-combinations) as shown in A. Channel numbers are given at the top and to the right of each matrix. The white broken lines separate within-row cross correlations (upper and lower sub-triangles) and between-rows cross correlations (rectangular area). Note that within-row cross correlations decrease in a monotonic fashion with distance between the electrodes in a pair.
Kreuzer et al. BMC Neuroscience 2010 11:122 doi:10.1186/1471-2202-11-122