Table 1

Neuropsychological follow-up data (N = 36)

ANOVA for repeated measures


Baseline

Week 2-3

Week 6

Week 9

Month 3

Month 6

Month 12



Test parameter

Mean

SD

Mean

SD

Mean

SD

Mean

SD

Mean

SD

F4.32§

p1

d

Mean

SD

Mean

SD

F2.34

p2


ATTENTION

0.69


TAP Visual Scanning - critical trials

2401.0

604.8

2041.4

550.1

1908.2

519.9

1782.3

519.4

1712.0

550.1

14.64

<.001

1.19

1782.3

555.8

1728.8

548.6

2.57

.09


Trail Making Test - part A

29.3

10.7

24.9

9.0

24.5

8.9

22.8

8.6

23.3

12.0

4.43

.006

0.53

22.8

8.2

23.4

7.0

0.44

.65


RBANS Coding

51.6

9.6

56.0

10.6

52.2

9.0

54.5

9.7

55.1

10.0

9.74

<.001

0.36

54.8

10.3

54.9

8.8

0.05

.95


TAP Alertness - with cue sound

265.8

44.8

262.8

60.3

261.9

54.8

258.8

65.9

248.9

64.8

2.39

.07

-

254.4

46.7

264.0

70.3

1.89

.17


RBANS Digit Span

10.8

2.1

10.3

1.8

10.9

1.9

10.8

2.4

10.7

2.0

1.00

.42

-

11.1

2.2

11.3

1.9

2.27

.12


LEARNING AND MEMORY

0.67


RBANS Figure Recall

16.6

2.9

-

-

18.4

2.1

-

-

18.4

1.8

11.65

<.001

0.75

18.8

1.3

18.6

1.6

0.57

.57


RBANS List Recall

7.1

2.2

-

-

7.9

2.0

-

-

8.4

1.6

13.28

<.001

0.68

8.9

1.4

8.4

1.7

2.33

.11


RBANS List Learning

31.3

3.6

-

-

32.7

4.5

-

-

33.8

3.7

9.05

.001

0.68

34.8

3.6

33.7

3.7

2.05

.14


RBANS Story Memory

18.1

4.1

-

-

18.3

3.5

-

-

20.5

2.8

16.74

<.001

0.68

19.8

3.3

19.9

3.7

1.56

.22


RBANS Story Recall

9.6

1.9

-

-

9.2

1.7

-

-

10.5

1.4

15.79

<.001

0.54

9.9

1.9

10.4

1.6

2.50

.10


RBANS List Recognition

19.8

0.5

-

-

19.7

0.6

-

-

19.7

0.8

0.54

.59

-

19.7

0.6

19.7

0.7

0.07

.93


EXECUTIVE FUNCTIONS

0.50


Trail Making Test - part B

70.1

28.5

61.4

29.9

59.7

29.1

52.5

19.5

50.6

22.9

11.68

<.001

0.75

54.8

26.9

53.7

23.7

0.88

.42


WCST-64 - perseverative errors

9.2

4.8

-

-

7.4

5.0

-

-

6.6

4.2

6.00

.006

0.58

6.3

4.8

7.2

5.3

0.59

.56


TAP Flexibility

858.9

320.8

783.6

351.8

750.3

325.8

698.0

332.9

697.9

329.9

7.46

<.001

0.49

685.7

345.7

682.0

305.6

0.32

.73


WMS-III Letter Number Sequencing

11.4

2.5

12.3

2.3

12.2

2.3

12.6

2.8

12.7

3.0

6.30

.001

0.47

12.9

2.7

12.9

2.9

0.19

.83


RWT phonemic verbal fluency

53.6

14.0

60.0

18.0

60.3

16.6

62.8

15.2

56.4

16.1

10.55

<.001

0.19*

61.2

18.2

63.8

18.3

16.38

<.001


TAP Working Memory

568.3

160.4

547.7

144.7

569.6

155.7

565.6

176.5

533.0

150.4

1.55

.21

-

528.3

161.0

533.3

139.3

0.06

.94


MOTOR FUNCTIONS

0.56


9-Hole Peg Test - dominant hand

18.1

2.5

17.4

2.1

16.8

2.4

16.7

2.2

16.5

2.4

7.11

<.001

0.65

16.4

2.3

16.2

2.0

1.29

.29


Purdue Pegboard Test - assembly

32.4

8.2

33.6

8.5

34.1

8.0

35.0

8.4

36.7

8.3

8.82

<.001

0.52

35.8

9.2

35.5

9.4

1.70

.20


MacQuarrie Tapping

39.2

7.5

41.4

7.0

41.5

7.8

43.0

8.2

43.1

7.7

13.08

<.001

0.51

42.5

8.2

42.3

7.7

1.93

.16


MacQuarrie Dotting

66.3

12.4

70.0

12.1

69.8

12.3

70.1

11.1

71.2

10.3

2.21

.09

-

71.2

12.0

69.5

12.7

1.86

.17


LANGUAGE

0.00


RBANS Picture Naming

10.0

0.0

-

-

9.7

0.5

-

-

10.0

0.2

7.76

.002

0.00*

9.8

0.4

10.0

0.0

4.86

.01


RBANS Semantic Fluency

23.2

5.2

-

-

25.0

4.8

-

-

24.4

4.5

2.41

.11

-

25.0

5.2

23.5

5.4

1.62

.21


VISUOSPATIAL FUNCTIONS

-


RBANS Lines

18.1

2.8

-

-

18.5

2.0

-

-

18.7

1.5

1.00

.38

-

18.6

1.4

19.0

1.8

1.23

.30


RBANS Figure Copy

19.9

0.4

-

-

19.9

0.4

-

-

19.9

0.2

0.50

.61

-

19.9

0.4

19.8

0.4

1.33

.28


Significant ANOVA (analysis of variance) time effects bolded. §In case of only 3 testings until month 3, df = 2.34. p1 displays significance from baseline to month 3; p2 denotes significance from month 3 to month 12. Cohen's d = (μmonth 3 - μbaseline)/σpooled with d = 0.20-0.49 denoting small, d = 0.50-0.79 moderate, and d ≥ 0.80 large effect sizes. *indicates d < 0.20, i.e. "no effect". Effect sizes presented only if respective differences over time are significant (p < 0.01). Cohen's d for cognitive domains expressed as mean of single-test effect sizes of the respective cognitive domain.

TAP, Test for Attentional Performance; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; WCST-64, Wisconsin Card Sorting Test - 64 Card Version; WMS-III, Wechsler Memory Scale - 3rd edition; RWT, Regensburger Wortflüssigkeitstest.

Bartels et al. BMC Neuroscience 2010 11:118   doi:10.1186/1471-2202-11-118

Open Data