R6/2 mice show increased migration of neuroblasts to the affected striatum compared to controls, without signs of substantial striatal neurogenesis. Representative images of DCX-expressing neuroblasts in wild-type (WT; A) and R6/2 mice (R6/2; B), higher magnification (from insert in B) of cells exhibiting heterogeneous morphologies (C): Some cells possess only short or no processes, some display multiple well-developed processes characteristic of migrating cells. Arrows indicate migrating DCX positive cells leaving the SVZ. Quantification of DCX-positive cells in the striatum of WT and R6/2 mice, predominantly in close proximity to the SVZ (D). Error bars represent SD, * indicates p < 0.05. Scale bars represent 50 μm.
Kohl et al. BMC Neuroscience 2010 11:114 doi:10.1186/1471-2202-11-114