Table 1

EphrinA5 protein distribution in the developing mouse brain

TELENCEPHALON

DIENCEPHALON

MESENCEPHALON

METENCEPHALON


E12.5

    Olfactory nerve

    Neocortex

    Piriform cortex

    LGE

    LGE dz
l. v.m. d.

    MGE dz
l. v.m. d.

    Preoptic dz

l. v.m. d.

    Preoptic area

    Ventral thalamus

v. r.d. c.

    Hypothalamus

v. r.d. c.

    Mesencephalic tegmentum

    Isthmus

    Cerebellum


E14.5

    Olfactory bulb

    Neocortex S1 (CP)

    Piriform cortex

    LGE
l. v. r.m. d. c.

    Subventricular zone

    Preoptic area

    Ventral thalamus

v. r.d. c.

    Subthalamic area

    Hypothalamus

    Mesencephalic tegmentum

    Superior colliculus

    Inferior colliculus

l.m.

    Pretectum

l. v.m. d.

    Commissure of superior colliculus

    Isthmus dz

    Cerebellar vermis


E16.5

    Olfactory structures: GCL, MCL, olfactory tubercle, lateral olfactory tract

    Septum

    LGE
v. r.d. c.

    Neocortex (MZ, CP, SP)

    Frontal cortex

    Parietal cortex (S1)

    Insular cortex

    Retrosplenial cortex

    Piriform cortex

    Hippocampus

    Preoptic area

    Thalamus

v. r.d. c.

    Hypothalamus

    Mesencephalic tegmentum

    Superior colliculus

    Inferior colliculus

c.r.

    Isthmus

    Cerebellar vermis

    Pons


E18.5

    Olfactory structures: GCL, olfactory tubercle, lateral olfactory tract

Striatum

Nucleus accumbens

    Septum
l. v.m. d.

    Lateral migratory stream

Piriform cortex

Insular cortex

Cingulate cortex

Retrosplenial cortex

    Perirhinal cortex

    Neocortex

    Parietal cortex (S1)

    Occipital cortex (layers I & V)

Hippocampus (CA1, CA3, DG)

    Thalamus

l. d.m. v.

Hypothalamus

Mesencephalic tegmentum

Superior colliculus

    Inferior colliculus

l.➤m.

Commissure of superior colliculus

Cerebellum

Pons


P0

Olfactory structures: GCL, subventricular zone, olfactory tubercle, lateral olfactory tract

Subventricular zone

Striatum l. v.m. d.

Nucleus accumbens

    Septum

Parietal cortex

Frontal cortex

Retrosplenial cortex

Thalamus

    Hypothalamus

Mesencephalic tegmentum

Superior colliculus

Inferior colliculus

c.r.

    Commissure of superior colliculus

Cerebellum


EphrinA5 was expressed in the same brain regions of the telencephalon, diencephalon, mesencephalon and metencephalon from E12.5, throughout the embryonic development until P0. The intensity of staining was high from E12.5 to E16.5 and then decreased until P0 to become non-existent in P7 animals (data not shown). The names of brain regions exhibiting a strong ephrinA5 protein expression were underlined and highlighted in bold, whereas names of brain structures showing a moderate ephrinA5 protein expression were only underlined. Names of brain regions exhibiting weak or non-existent ephrinA5 protein expression were not highlighted. Black arrowheads indicate ephrinA5 protein expression gradients. Abbreviations: see list.

Deschamps et al. BMC Neuroscience 2010 11:105   doi:10.1186/1471-2202-11-105

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