SOD-1, SOD-2 and HO-1 IR in the cerebellar cortex of CO-exposed rats and their age matched controls. Fig. (a), (a1) and (a2), SOD-1-IR in group A, B, and C respectively (appearing as an amber colored precipitate) was present in neurons of the molecular (M), Purkinje (P), and granular (G) layers (see arrows). (a3) group D shows normal SOD-1 IR. Fig. (b), and (b1), shows SOD-2-IR in neuronal bodies in M and P layers (see arrows). (b2) group C in contrast, showed less pronounced SOD-2-IR. (b3) group D shows normal SOD-2 IR. Fig. (c), and (c1), shows elevated HO-1-IR in neuronal bodies in M, P, and G layers (see arrows). (c2) group C, showed less pronounced HO-1-IR. (b3) control group D shows basal HO-1-IR. Hematoxylin (in purple color) identifies cell nuclei. Bar in all Figs. is 150 um.
Lopez et al. BMC Neuroscience 2009 10:53 doi:10.1186/1471-2202-10-53