Table 1

Effects of HIV-1 on GSH/GSSG ratio, a sensitive indicator of oxidative stress

GSH/GSSG (% Control)


TIME (Day)

1

2

3


CTRL

100 ***

100**

100 ***

HIV

51 ± 6.2 §

46 ± 6.3§

35 ± 2.8 §

HIV + NAC

72 ± 4.3

68 ± 8.7

48 ± 5.1


The GSH/GSSG ratio, in U373 exposed to HIV-1 IIIB, decreases compared with control of not HIV-1 exposed cells. The ratio significantly increased with NAC treatment. *p < 0.05, **p < 0.01, ***p < 0.001 when compared vs control; §p < 0.05, §§ p < 0.01, §§§ p < 0.001, when compared vs HIV.

Pollicita et al. BMC Neuroscience 2009 10:51   doi:10.1186/1471-2202-10-51

Open Data