cAMP and NT-3 level in the injured spinal cord. A. cAMP levels in the lesion tissue were measured by radioimmunoassay. In the MSCs+EA group, cAMP levels in the lesioned tissue were significantly higher as compared to the other groups. *P < 0.001. Data = means ± SD. B. NT-3 contents in the segments rostrally and caudally to the lesion site, and the lesion site were measured by ELISA. In all three areas, the NT-3 contents were significantly increased in the EA, MSCs, and MSCs+EA groups as compared to the Op-control group (* indicates P < 0.01). In the lesion site, the NT-3 contents were significantly higher in the MSCs+EA group than the MSCs and EA groups (# indicates P < 0.01). Moreover, the NT-3 contents in the rostral and caudal segments to the lesion site in the MSCs+EA group had no significant difference as compared to the Sham-control group (P > 0.05). Data= means ± SD.
Ding et al. BMC Neuroscience 2009 10:35 doi:10.1186/1471-2202-10-35