Plasma Cortisol responses to central cortisol secretion. Simulations shows the effects of a) increased and b) decreased somatic tissue utilisation of cortisol on plasma cortisol levels. Simulation of the response of the model to parameters were changed by a factor of 10–50% inducing changes in circulating cortisol levels as described in accompanying tables, modelled using SBML as detailed in the methods section.
McAuley et al. BMC Neuroscience 2009 10:26 doi:10.1186/1471-2202-10-26