Generation analysis of CD8+ cells isolated from MOG-primed wt and mmp7-/- mice, using CFSE. (a, b) The proportion of IL-2-responsive progenitors that gave rise to CD8+ cells in wt mice was comparable to that observed with (d, e) MMP-7-/- mice. (c, f) MOG-responses were robust in wt, but not mmp7-/- progenitors. Percentages indicate the proportion of progenitors that surpassed the farthest generation of media-only controls (a, d).
Buhler et al. BMC Neuroscience 2009 10:17 doi:10.1186/1471-2202-10-17