MR Spectroscopy voxel location, metabolic measures across batteries and schematic representing correlations between behavioural performance and metabolism. A) Localisation of the left and right posterior hippocampal voxels (2 cm × 2 cm × 2 cm) used in MRS scanning. B) MRS metabolism as measured by ratio of NAA/(tCr+Cho) at the left and right posterior hippocampal voxels. At Week 12/Scan 2, Group A (heavy line, filled squares) had a significantly larger ratio than Group B (thin line, empty squares) for the left posterior hippocampus; no significant change was observed at the right posterior hippocampal voxel.
Roche et al. BMC Neuroscience 2009 10:136 doi:10.1186/1471-2202-10-136