Table 3 |
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Clustering of the genes whose expression is altered in the choroid plexus upon repeated peripheral LPS injection. |
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Atered genes |
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3 days |
15 days |
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Signaling pathways |
Toll like receptor signaling |
Tlr7; Mapk8; Cd14; Relb ↑ |
- |
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T cell receptor signaling |
Mapk8; Nfat5;Btk; Vav1; Relb ↑; Rras2; Nfatc1 ↓ |
Itk ↑ |
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B cell receptor signaling |
Fcgr2a; Bcl2a1; Mapk8; Nfat5; Map2k7; Rac2; Fcgr2b; Inpp5d; Btk; Vav1; Relb ↑; Rras2; Nfatc1; Bcl2l1 ↓ |
- |
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SAPK JNK signaling |
Gpr65; Gpr24; Mapk8; Map2k7; Rac2; Sh2d2a ↑; Rras2; Fadd; Nfatc1; Egfr ↓ |
Gng11;Gpr34 ↑; Dusp8 ↓ |
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Natural killer signaling |
Fcer1g; Tyrobp; Siglec7; Rac2; Klrd1; Inpp5d; Vav1; Hcst ↑; Rras2 ↓ |
Klrd1; Siglec7 ↑ |
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NF-kB signaling |
Tlr7; Tnfsf13b; Mapk8; Map2k7; Relb ↑; Rras2; Egf; Tnfsf11; Egfr ↓ |
Tnfsf13b ↑ |
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JAK/STAT signaling |
Stat3 ↑; Rras2 ↓ |
- |
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cAMP mediated signaling |
Rgs10; Grm3; Stat3 ↑; Gnai; Grk4; Cngb1; Rgs12 ↓ |
Adcy9; Crem ↓ |
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Interferon signaling |
Isgf3g; Tap1; Ifngr2; Ifitm1; Ifitm3; Ifi205; Irf5; Ifngr2 ↑ |
Ifitm1 ↑ |
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GM-CSF signaling |
Bcl2a1; Stat3 ↑; Rras2; Bcl2l1 ↓ |
- |
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Integrin signaling |
Mapk8; Actin4; Rac2 ↑; Rras2; Egfr ↓ |
Itgae; Itgb7 ↑ |
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IL-10 signaling |
Il10ra; Tcgr2a; Mapk8; Cd14; Fcgr2b; Stat3; Relb ↑ |
- |
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IL-6 signaling |
Mapk8; Map2k7; Cd14; Stat3; Relb ↑; Rras2 ↓ |
- |
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IL-4 signaling |
Nfat5; Il2rg; Inpp5d ↑; Rras2; Nfatc1 ↓ |
- |
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IL-2 signaling |
Mapk8; Il2rg ↑; Rras2 ↓ |
- |
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Complement/coagulation cascade signaling |
C3; C1qa; C1qb; C1qg; Vwf; Serping1; C2 ↑ |
Serpind1; C1qg; C1qa; C3 ↓ |
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Apoptosis signaling |
Casp1; Bcl2a1; Mapk8; Map2k7; Relb ↑; Rras2; Bcl2l1; Ecfr; Bcl2 ↓ |
Card14 ↑ |
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Antigen presentation pathway |
B2m; H2-T23; Tap1; Psmb9 ↑ |
- |
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Acute phase response |
Acute phase proteins |
Serping1; Map2k7; C3; Mapk8;Saa3;Vwf; Stat3; Slp; C2; serpina3n ↑; Fn1; Rras2 ↓ |
C3 ↑ |
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Leukocyte migration |
Leukocyte extravasation signaling |
Ncf2; Selpl; Mapk8; Cyba; Jam2; Actn4; Rac2; Mmp23; Icam1; Glycam1; Madcam1; Timp1; Btk; Vav1 ↑; Gnai ↓ |
Icam1; Itk; Cyba ↑ |
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Extracellular matrix |
Timp1; Dcn; Lamb2; Fbln1; Mmp23; Tecta; Emid1 ↑; Fn1 ↓ |
Tnc; Spon2 ↓ |
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Cytokine signaling |
Il16; Ccl5; Cxcl1; Ccl7; Ccl13; Xcl1; Cxcl16; Ccl2 ↑; Gnai1; Rras2 ↓ |
Cxcl1; Ccl7; Xcl1; Ccl2 ↑ |
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Actin cytoskeleton signaling |
Nckap1l; Gpr65; Gpr34; Actn4; Kng1; Rac2; Cd14; Vav1 ↑; Rras2; Fgf7; Egf; Myh14; Fn1; Egfr ↓ |
Gpr34 ↑ |
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Axonal guidance signaling |
Igf1; Nfat5; Rac2; Fes ↑; Gnai1; Slit2; Rras2; Rgma; Nfatc1; Egf; Egfr ↓ |
Rgmb ↑ |
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Marques et al. BMC Neuroscience 2009 10:135 doi:10.1186/1471-2202-10-135 |
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