Cerebral infarct analysis of stroke brains. TTC staining revealed that low dose minocycline (20 mg/kg; B) significantly reduced cerebral infarct volumes compared to the vehicle group (A). In particular, the striatal infarct volumes in the low dose group were significantly smaller than the vehicle group. In contrast, high dose minocycline (100 mg/kg; C) significantly increased the infarct volumes compared to those in the vehicle group. Quantitative analyses are shown in panel D. Data represent mean values ± SEM (*p < 0.05).
Matsukawa et al. BMC Neuroscience 2009 10:126 doi:10.1186/1471-2202-10-126