Table 2

Binding of [³H]-PK11195 following cortical contusion injury in COX-2 +/+ and COX-2 -/- mice.

COX-2 +/+

COX-2 -/-

Brain Region

Uninjured

Injured

Uninjured

Injured

CA1

3.22 ± 0.82

3.88 ± 0.47*

2.97 ± 0.61

4.89 ± 1.43*†

CTX

2.72 ± 0.43

4.05 ± 0.87*

2.77 ± 0.42

4.09 ± 0.70*

DLG

2.28 ± 0.20

3.36 ± 0.84*

2.24 ± 0.31

3.40 ± 0.66*

LPM

2.51 ± 0.23

3.40 ± 0.62*

2.52 ± 0.30

3.68 ± 0.92*

DG

4.66 ± 1.17

5.87 ± 0.80*

4.36 ± 0.96

6.63 ± 1.59*†

VPL/VPM

2.02 ± 0.14

2.41 ± 0.20*

1.97 ± 0.25

2.45 ± 0.41*

Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemisphere; † represents significant changes compared to the corresponding hemisphere of the COX-2 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.

Kelso et al. BMC Neuroscience 2009 10:108   doi:10.1186/1471-2202-10-108