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The criteria for the EE-element. Criteria for the EE-element are as follow: 1) 2 E-boxes, close to each other, are needed, 2) E1 E-box allows 1 base mismatch, E2 E-box allows 2 base mismatches, 3) the spacing between 2 E-boxes is 6 or 7 bp, and 4) the element is located within 1 kb upstream region from the TSS. |
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| E-box |
space |
E-box |
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| C A C G T G |
6 or 7 bp |
C A C G T G |
| 0~1 mismatch |
0~2 mismatch |
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Nakahata et al. BMC Molecular Biology 2008 9:1 doi:10.1186/1471-2199-9-1 |
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