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Open Access Highly Accessed Research article

Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries

Abbie M Adams1, Penny L Harding1, Patrick L Iversen2, Catherine Coleman1, Sue Fletcher1 and Steve D Wilton1*

Author Affiliations

1 Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia

2 AVI BioPharma, 4575 SW Research Way, Corvallis, Oregon, USA

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BMC Molecular Biology 2007, 8:57  doi:10.1186/1471-2199-8-57

Published: 2 July 2007

Additional files

Additional file 1:

Sequences of AOs designed and evaluated for inducing excision of human dystrophin exon 20. Reference numbers may be used to orientate the annealing coordinates shown in Figure 1.

Format: XLS Size: 12KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

Sequences of AOs designed and evaluated for inducing excision of human dystrophin exon 65. Reference numbers may be used to orientate the annealing coordinates shown in Figure 2.

Format: XLS Size: 10KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Sequences of AOs designed and evaluated for inducing excision of human dystrophin exons 10 and 67.

Format: XLS Size: 10KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Summary of AO combinations evaluated for targeted removal of human dystrophin exons. Serine-arginine rich protein (SR) binding scores for each AO in the combination are shown. The efficiency of exon removal is indicated (*). (n/a-not applicable).

Format: XLS Size: 24KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data