Distribution of YBX3 expression ratios in tumor samples according to histological grading. (A) Circles are values for YBX3-Ψ expression ratios in the 15 Fuhrman-graded tumors compared to paired adjacent healthy tissue after normalization to geometric mean of PPIA + RPS13. Lines are medians for each group and statistical differences between subgroups are indicated as well (Mann Whitney test, *p < 0.05, **p < 0.01). The expression of YBX3 inversely correlates with tumor grade. (B) Representative images of YBX3 protein staining in tumor samples. Note (i) absence of nuclear labeling in stromal nuclei; (ii) overall decrease of intensity from grade #1 to #3; (iii) occasional cytoplasmic labeling in grade #2; and (iv) marked heterogeneity of nuclear labeling in some fields of grade #3 only. Scale bar; 50 μm.
Dupasquier et al. BMC Molecular Biology 2014 15:9 doi:10.1186/1471-2199-15-9