Additional file 2.

Supplemental Figure 1. Unmatched preparations show poor consistency in identifying changes in MNase protection signals. Supplemental Figure 2. Matched MNase digests identify biologically relevant differences in chromatin structure. Supplemental Figure 3. Comparison between wild-type and tup1? MNase-seq experiments at a single region of Tup1-dependent chromatin. Supplemental Figure 4. The ability of matched MNase digests to specifically detect biologically-relevant differences in chromatin structure is NOT dependent on dissimilarity cutoff values used in analysis. Supplemental Figure 5. MNase cut probability function for nucleosomal DNA templates. Supplemental Table 1: MNase-seq datasets used in this study.

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Rizzo et al. BMC Molecular Biology 2012 13:15   doi:10.1186/1471-2199-13-15