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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor J. Ann Le Good PhD
Welcome to BMC Molecular Biology published by BioMed Central
BMC Molecular Biology is an open access journal publishing original peer-reviewed research articles in all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function.
BMC Molecular Biology (ISSN 1471-2199) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Thomson Reuters (ISI) and Google Scholar.
BMC Molecular Biology 2009, 10 :101
The hypoxia-tolerant grass carp has two CITED3 genes whose promoters bind HIF-1 as they are induced by hypoxia in the liver and kidneys, and whose products are co-transcriptional regulators that interact with p300 and affect HIF-1 activity.
BMC Molecular Biology 2009, 10 :89
Monomers of the transcriptional regulator C-terminal binding protein 2 (CtBP2) bind competitively to the PLDLS-motif cofactor zinc-finger E-box binding homeobox (ZEB) and the histone deacetylase HDAC2, but do not mediate transcriptional repression, while dimers which bind both are functional.
BMC Molecular Biology 2009, 10 :85
Levels of the transcription factor Yin Yang 1 (YY1), which controls many genes and biological processes in vertebrates, is self-regulated through internal DNA-binding sites.
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Research article
Functional characterization of two CITED3 homologs (gcCITED3a and gcCITED3b) in the hypoxia-tolerant grass carp, Ctenopharyngodon idella Patrick KS Ng, Sung-Kay Chiu, Theresa FN Kwong, Richard MK Yu, Minnie ML Wong, Richard YC Kong BMC Molecular Biology 2009, 10 :101 (3 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Evaluation of real-time PCR endogenous control genes for analysis of gene expression in bovine endometrium Caroline G Walker, Susanne Meier, Murray D Mitchell, John R Roche, Mathew Littlejohn BMC Molecular Biology 2009, 10 :100 (1 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae Marie-Ange Teste, Manon Duquenne, Jean M Francois, Jean-Luc Parrou BMC Molecular Biology 2009, 10 :99 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions Ellen C Ordinario, Munehisa Yabuki, Priya Handa, W Jason Cummings, Nancy Maizels BMC Molecular Biology 2009, 10 :98 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Preliminary molecular characterization of the human pathogen Angiostrongylus cantonensis Hualiang He, Mei Cheng, Xiao Yang, Jinxiu Meng, Ai He, Xiaoying Zheng, Zhuoya Li, Pengjuan Guo, Zhihua Pan, Ximei Zhan BMC Molecular Biology 2009, 10 :97 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Dual effect of a single nucleotide polymorphism in the first intron of the porcine Secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing Eduard Mur BMC Molecular Biology 2009, 10 :96 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
A small intergenic region drives exclusive tissue-specific expression of the adjacent genes in Arabidopsis thaliana Hern BMC Molecular Biology 2009, 10 :95 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes Casper Bindzus Foldager, Samir Munir, Michael Ulrik-Vinther, Kjeld S BMC Molecular Biology 2009, 10 :94 (9 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Evaluation of putative reference genes for gene expression normalization in soybean by quantitative real-time RT-PCR Ruibo Hu, Chengming Fan, Hongyu Li, Qingzhu Zhang, Yong-Fu Fu BMC Molecular Biology 2009, 10 :93 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
From sequence to dynamics: the effects of transcription factor and polymerase concentration changes on activated and repressed promoters Abel Gonz BMC Molecular Biology 2009, 10 :92 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Short Report
Francisella tularensis subsp. novicida isolated from a human in Arizona Dawn N Birdsell, Tasha Stewart, Amy J Vogler, Elisabeth Lawaczeck, Alisa Diggs, Tammy L Sylvester, Jordan L Buchhagen, Raymond K Auerbach, Paul Keim, David M Wagner BMC Research Notes 2009, 2 :223 (6 [Abstract ] [Provisional PDF ]
Short report
Bioinformatic evidence for a stem-loop structure 5'-adjacent to the IGR-IRES and for an overlapping gene in the bee paralysis dicistroviruses Andrew E Firth, Qing S Wang, Eric Jan, John F Atkins Virology Journal 2009, 6 :193 (6 [Abstract ] [Provisional PDF ]
Research
Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle. Esther Castellano, Carmen Guerrero, Alejandro Nunez, Javier De Las Rivas, Eugenio Santos Genome Biology 2009, 10 :R123 (6 [Abstract ] [Provisional PDF ]
Review
Pathophysiology of vascular dementia Francesco Iemolo MD, Giovanni Duro DR, Claudia Rizzo MD, Laura Castiglia DR, Vladimir Hachinski MD, Calogero Caruso MD Immunity & Ageing 2009, 6 :13 (6 [Abstract ] [Provisional PDF ]
Research article
A selective eradication of human non-hereditary breast cancer cells by phenanthridine derived polyADP-ribose polymerase inhibitors
Dana Inbar-Rozensal, Asher Castiel, Leonid Visochek, David Castel, Francoise Dantzer, Shai Izraeli, Malka Cohen-Armon Breast Cancer Research 2009, 11 :R78 (5 [Abstract ] [Provisional PDF ]
Research
Detection and quantification of pestivirus in experimentally infected pregnant ewes and their progeny Ana Hurtado, Isbene Sanchez, Felix Bastida, Esmeralda Minguijon, Ramon A Juste, Ana L Garcia-Perez Virology Journal 2009, 6 :189 (5 [Abstract ] [Provisional PDF ]
Research
Aurora-A down-regulates IkappaB alpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival Jin-e Yao, Min Yan, Zhong Guan, Chao-bin Pan, Liang-ping Xia, Chuan-xing Li, Li-hui Wang, Zi-jie Long, Yan Zhao, Ming-wei Li, Fei-meng Zheng, Jie Xu, Dong-jun Lin, Quentin Liu Molecular Cancer 2009, 8 :95 (5 [Abstract ] [Provisional PDF ]
Research article
Comparative proteomic analysis of malformed umbilical cords from somatic cell nuclear transfer-derived piglets: implications for early postnatal death Jong-Yi Park, Jae-Hwan Kim, Yun-Jung Choi, Kyu-Chan Hwang, Seong-Keun Cho, Ho-Hyun Park, Seung-Sam Paik, Teoan Kim, ChanKyu Park, Hoon Taek Lee, Han Geuk Seo, Soo-Bong Park, Seongsoo Hwang, Jin-Hoi Kim BMC Genomics 2009, 10 :511 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus Louise A Russo, Bryan J Peano, Shreya P Trivedi, Todd D Cavalcanto, Benjamin A Olenchock, Joseph A Caruso, Amanda R Smolock, Oleg Vishnevsky, Russell M Gardner Reproductive Biology and Endocrinology 2009, 7 :124 (4 [Abstract ] [Provisional PDF ]
Research article
Expression of SORL1 and a novel SORL1 splice variant in
normal and Alzheimers disease brain
Karrie E Grear, I-Fang Ling, James F Simpson, Jennifer L Furman, Christopher R Simmons, Shawn L Peterson, Frederick A Schmitt, William R Markesbery, Qiang Liu, Julia E Crook, Steven G Younkin, Guojun Bu, Steven Estus Molecular Neurodegeneration 2009, 4 :46 (4 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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