- Stephen Bustin, Barts and the London School of Medicine and Dentistry
- Frances V Fuller-Pace, University of Dundee
- Stuart MacNeill, University of St. Andrews
- Toshio Tsukiyama, Fred Hutchinson Cancer Research Center
- Christian Zwieb, University of Texas Health Science Center at Tyler
- Tim Sands, BioMed Central
Analysis of miRNA expression profiling between the porcine longissimus doris muscle and psoas major muscle using a deep sequencing approach suggests that miRNAs play essential roles in the phenotypic variations observed in these muscle fiber types.
Pseudo splice sites are heterogeneously distributed along exon 26 of Apolipoprotein B and are repressed by multiple, tandem splicing silencers which may be key to maintaining integrity during RNA splicing and to the expression of APOB isoforms.
Muscleblind-like (MBNL) splicing proteins MBNL1 and MBNL2 positively regulate the inclusion of neurofibromatosis type 1 (NF1) exon 23a, and neighboring sequences together with the preferred binding sequence are required for optimal binding in vitro.
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BMC Molecular Biology 2013, 14:7
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BMC Molecular Biology is an open access, peer-reviewed journal that considers articles on all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function.
It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.
Nicholas W Ashton, Emma Bolderson, Liza Cubeddu, Kenneth J O¿Byrne and Derek J RichardBMC Molecular Biology 2013, 14:9 (1 April 2013)
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Section Editor's profile
Stuart MacNeill is currently a Reader in Translational Biology at the University of St Andrews. Dr MacNeill’s research is focused on dissecting the molecular machinery of chromosome DNA replication and genome stability in eukaryotic and archaeal cells using the fission yeast Schizosaccharomyces pombe, and the genetically-tractable halophilic archaeal organism Haloferax volcanii as model systems. He is also involved in collaborative research on the nuclear DNA replication apparatus of kinetoplastid parasites aimed at identifying novel drug targets.
"BMC Molecular Biology is an excellent platform for rapid, open access publication of high quality research in the molecular biosciences. The ‘DNA replication and genome stability’ section welcomes submissions covering all aspects of replication, repair and recombination, encompassing a wide variety of research methods, from fundamental genetic studies through to protein structure determination."