BMC Microbiology

official impact factor 2.96

Open Access Research article

Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization

Jing Chen1, Liang Zhang1, Yu Zhang1, Haitao Zhang1, Jiamu Du2, Jianping Ding2, Yuewei Guo1*, Hualiang Jiang1 and Xu Shen1*

Author Affiliations

1 Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China

2 Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, PR China

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BMC Microbiology 2009, 9:91 doi:10.1186/1471-2180-9-91

Published: 12 May 2009

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Additional file 1:

Supplemental Materials. Supplemental Figure Legends.

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Additional file 2:

Supplemental Figure S1. pH profile of HpFabZ enzyme activity.

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Additional file 3:

Supplemental Figure S2. The effect of DMSO on HpFabZ enzyme activity.

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