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Open Access Research article

The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes

Mauricio Alvarez, Tamika Burn, Yong Luo, Liise-anne Pirofski and Arturo Casadevall*

Author Affiliations

Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA

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BMC Microbiology 2009, 9:51  doi:10.1186/1471-2180-9-51

Published: 5 March 2009

Additional files

Additional file 1:

Replication of C. neoformans within human peripheral blood monocytes. The data provided represents intracellular replication of C. neoformans in HPBM cells at rates similar to extracellular C. neoformans (every 2 to 3 h).

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Open Data

Additional file 2:

Cell to cell spread of C. neoformans in human peripheral blood monocytes. Cell to cell spread was witnessed following ingestion and subsequent imaging of infected HPBMs, we witnessed that C. neoformans also spread from host human monocyte to another uninfected one.

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Open Data