CAPIH: A Web interface for comparative analyses and visualization of host-HIV protein-protein interactions
1 Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, 350 Taiwan, Republic of China
2 Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, Republic of China
3 Department of Life Science, National Chiao-Tung University, Hsinchu, 300 Taiwan, Republic of China
4 Department of Dentistry, Chinese Medical University, Taichung, 404 Taiwan, Republic of China
BMC Microbiology 2009, 9:164 doi:10.1186/1471-2180-9-164Published: 12 August 2009
The Human Immunodeficiency Virus type one (HIV-1) is the major causing pathogen of the Acquired Immune Deficiency Syndrome (AIDS). A large number of HIV-1-related studies are based on three non-human model animals: chimpanzee, rhesus macaque, and mouse. However, the differences in host-HIV-1 interactions between human and these model organisms have remained unexplored.
Here we present CAPIH (
CAPIH exemplifies that large divergences exist in disease-associated proteins between human and the model animals. Since all of the newly developed medications must be tested in model animals before entering clinical trials, it is advisable that comparative analyses be performed to ensure proper translations of animal-based studies. In the case of AIDS, the host-HIV-1 protein interactions apparently have differed to a great extent among the compared species. An integrated protein network comparison among the four species will probably shed new lights on AIDS studies.