|
Clinical characteristics of the studied subjects. |
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| Characteristics |
Active CD |
Non-active CD |
Control |
|
|
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| Number of patients |
30 |
18 |
30 |
| Age (average months and SD) |
56.4 (38.5) |
65.2 (37.7) |
45.0 (33.5) |
| Gender |
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| - male |
12/30 (40.0%) |
8/18 (44.4%) |
13/30 (43.3%) |
| - female |
18/30 (60.0%) |
10/18 (55.6%) |
17/30 (56.7%) |
| Clinical |
|||
| - Abdominal |
2/30 (6.6%) |
- |
- |
| - Diarrhoea |
28/30 (93.4%) |
2/18 (11.1%) |
- |
| - Weight loss |
9/30 (30.0%) |
- |
- |
| - Anaemia |
14/30 (46.6%) |
8/18 (44.4%) |
- |
| Biochemical |
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| - Asymptomatic |
4/30 (13.3%) |
18/18 (100%) |
- |
| - Iron deficiency |
10/30 (33.3%) |
- |
- |
| Serology |
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| AGA (anti-gliadin antibodies) |
AGA + (100%) |
AGA + (0%) |
AGA + (0%) |
| t-TG (anti-transglutaminase antibodies) |
t-TG + (100%) |
t-TG + (0%) |
t-TG + (0%) |
| Duodenal Biopsy a |
M3 (100%) |
M0-1 (100%) |
M0-1 (100%) |
|
a Modified Marsh Classification of CD[18]. M0: Normal mucosa; CD highly unlikely. M01: (Infiltrative lesion): Seen in patients on a gluten-free diet (suggesting minimal amounts of gliadin are being ingested); patients with dermatitis herpetiformis (DH); and family members of patients with CD. M2 (Hyperplasic type): seen occasionally in DH. M3: > 40 Intraepithelial Lymphocytes per 100 Enterocytes, crypts increased and villi with atrophy (partial or complete villous atrophy). | |||
Collado et al. BMC Microbiology 2008 8:232 doi:10.1186/1471-2180-8-232 |
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