Table 4

Time kill curve against β-lactamase positive H. influenzae (n = 50)
Antibiotic
Changes in colony counts vs initial inocula after




3 h
 6 h
 12 h
 24 h




CO2
 Air
 CO2
 Air
 CO2
 Air
 CO2
 Air
Telithromycin
 4 × MIC
 -1.28
 -1.44
 -2.74
 -2.80
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.37
 -0.89
 -1.57
 -1.77
 -2.77
 -2.88
 > -3.0
 > -3.0

1 × MIC
 -0.53
 -0.16
 -0.82
 -0.76
 -0.96
 -1.12
 -1.51
 -1.62

1/2 × MIC
 -0.13
 -0.04
 1.06
 0.13
 1.33
 1.61
 3.59
 2.08

1/4 × MIC
 0.33
 0.41
 1.66
 1.29
 2.46
 2.74
 4.03
 3.19

ELF
 -1.00
 -0.96
 -2.68
 -2.72
 > -3.0
 > -3.0
 > -3.0
 > -3.0
Clarithromycin
 4 × MIC
 -1.47
 -0.88
 -2.00
 -2.22
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.80
 -0.30
 -1.14
 -1.51
 -1.42
 -1.86
 > -3.0
 > -3.0

1 × MIC
 -0.27
 -0.06
 -0.79
 -0.60
 -1.31
 -1.61
 -1.40
 -1.86

1/2 × MIC
 0.52
 0.45
 2.43
 2.42
 2.36
 2.38
 2.63
 2.84

1/4 × MIC
 0.71
 0.69
 2.69
 2.47
 2.73
 3.25
 3.91
 3.98

ELF
 -0.91
 -1.22
 -2.65
 > -3.0
 > -3.0
 > -3.0
 > -3.0
 > -3.0
Azithromycin
 4 × MIC
 -1.49
 -2.22
 -2.61
 -2.85
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.98
 -1.68
 -1.65
 -1.93
 > -3.0
 > -3.0
 > -3.0
 > -3.0

1 × MIC
 -1.03
 -0.64
 -1.23
 -0.48
 -1.43
 -0.68
 -1.62
 -0.23

1/2 × MIC
 -0.67
 -0.15
 -0.03
 1.86
 0.47
 1.93
 3.67
 2.18

1/4 × MIC
 0.29
 0.26
 1.58
 1.96
 2.34
 2.13
 4.12
 3.28

ELF
 -1.05
 -1.20
 -2.27
 -2.53
 > -3.0
 > -3.0
 > -3.0
 > -3.0
Control
0.62
 0.73
 2.38
 2.49
 4.02
 4.13
 4.44
 4.55

De Vecchi et al. BMC Microbiology 2008 8:23   doi:10.1186/1471-2180-8-23