Table 3

Time kill curve against β-lactamase negative H. influenzae strains (N = 200)
Antibiotic
Mean changes in colony counts vs initial inocula after




3 h
 6 h
 12 h
 24 h




CO2
 Air
 CO2
 Air
 CO2
 Air
 CO2
 Air
Telithromycin
 4 × MIC
 -1.42
 -1.72
 - 2.81
 -2.61
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.64
 -0.18
 -1.87
 -1.91
 -2.71
 -2.45
 > -3.0
 > -3.0

1 × MIC
 -0.36
 -0.15
 -0.99
 -0.26
 -1.21
 -1.18
 -1.32
 -1.81

1/2 × MIC
 0.22
 0.39
 1.20
 0.85
 2.27
 2.43
 3.74
 4.12

1/4 × MIC
 0.43
 0.35
 1.51
 1.35
 2.94
 2.54
 4.93
 4.59

ELF
 -1.43
 -1.54
 -2.43
 > -3.0
 > -3.0
 > -3.0
 > -3.0
 > -3.0
Clarithromycin
 4 × MIC
 -1.03
 -0.94
 -2.18
 -2.32
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.75
 -0.69
 -1.80
 -1.61
 -2.42
 -2.30
 > -3.0
 > -3.0

1 × MIC
 -0.23
 -0.49
 -0.75
 0.66
 -0.91
 -1.04
 -1.18
 -1.58

1/2 × MIC
 -0.19
 -0.19
 0.69
 0.66
 1.57
 2.71
 3.81
 4.31

1/4 × MIC
 0.51
 0.45
 1.69
 1.40
 2.93
 2.99
 5.01
 4.84

ELF
 -1.09
 -1.26
 -2.68
 > -3.0
 > -3.0
 > -3.0
 > -3.0
 > -3.0
Azithromycin
 4 × MIC
 -1.99
 -1.38
 -2.86
 -2.44
 > -3.0
 > -3.0
 > -3.0
 > -3.0

2 × MIC
 -0.98
 -0.94
 -1.73
 -1.88
 > -3.0
 -2.57
 > -3.0
 > -3.0

1 × MIC
 -0.10
 -0.06
 -0.56
 -0.45
 -1.55
 -1.84
 -1.80
 -1.99

1/2 × MIC
 0.18
 0.29
 0.91
 1.03
 1.71
 2.31
 3.49
 3.41

1/4 × MIC
 0.39
 0.36
 1.38
 1.63
 2.23
 2.53
 4.58
 4.28

ELF
 -0.45
 -1.22
 -2.40
 -2.12
 -2.72
 -2.55
 > -3.0
 > -3.0
Control
0.64
 0.38
 1.96
 1.95
 4.32
 3.05
 5.44
 4.90

De Vecchi et al. BMC Microbiology 2008 8:23   doi:10.1186/1471-2180-8-23