BMC Microbiology

official impact factor 2.96

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Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: an initial draft to the two-dimensional annotation

Scott A Becker and Bernhard Ø Palsson*

BMC Microbiology 2005, 5:8 doi:10.1186/1471-2180-5-8

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BioMed Central: 25 citations

Methodology article   Open Access Highly Accessed

A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data

Min Li, Hanhui Zhang, Jian-xin Wang, Yi Pan BMC Systems Biology 2012, 6:15 (10 March 2012)

Database   Open Access Highly Accessed

MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases

Akhil Kumar, Patrick F Suthers, Costas D Maranas BMC Bioinformatics 2012, 13:6 (10 January 2012)

Research article   Open Access Highly Accessed

A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

Aarash Bordbar, Adam M Feist, Renata Usaite-Black, Joseph Woodcock, Bernhard O Palsson, Iman Famili BMC Systems Biology 2011, 5:180 (31 October 2011)

Research article   Open Access Highly Accessed

Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction

Kechi Fang, Hansheng Zhao, Changyue Sun, Carolyn M C Lam, Suhua Chang, Kunlin Zhang, Gurudutta Panda, Miguel Godinho, Vítor A P Martins dos Santos, Jing Wang BMC Systems Biology 2011, 5:83 (25 May 2011)

Software   Open Access Highly Accessed

Constructing a fish metabolic network model

Shuzhao Li, Alexander Pozhitkov, Rachel A Ryan, Charles S Manning, Nancy Brown-Peterson, Marius Brouwer Genome Biology 2010, 11:R115 (29 November 2010)

The first genome-wide fish metabolic model, MetaFishNet, is presented.

Database   Open Access Highly Accessed

BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions

Jan Schellenberger, Junyoung O Park, Tom M Conrad, Bernhard Ø Palsson BMC Bioinformatics 2010, 11:213 (29 April 2010)

Method   Open Access

Flux balance analysis accounting for metabolite dilution

Tomer Benyamini, Ori Folger, Eytan Ruppin, Tomer Shlomi Genome Biology 2010, 11:R43 (16 April 2010)

A flux balance analysis method for gene essentiality prediction, which takes into account variation in biomass composition under different growth conditions.

Research article   Open Access Highly Accessed

Comparative genomics of metabolic networks of free-living and parasitic eukaryotes

Barbara Nerima, Daniel Nilsson, Pascal Mäser BMC Genomics 2010, 11:217 (31 March 2010)

Research   Open Access

iBsu1103: a new genome-scale metabolic model of Bacillus subtilis based on SEED annotations

Christopher S Henry, Jenifer F Zinner, Matthew P Cohoon, Rick L Stevens Genome Biology 2009, 10:R69 (25 June 2009)

A new and validated genome-scale metabolic model of Bacillus subtilis 168, iBsu1103, is presented that has significantly improved completeness and accuracy.

Research   Open Access Highly Accessed

Metabolic-network-driven analysis of bacterial ecological strategies

Shiri Freilich, Anat Kreimer, Elhanan Borenstein, Nir Yosef, Roded Sharan, Uri Gophna, Eytan Ruppin Genome Biology 2009, 10:R61 (5 June 2009)

Bacterial ecological strategies revealed by metabolic network analysis show that ecological diversity correlates with metabolic flexibility, faster growth rate and intense co-habitation.

Research article   Open Access Highly Accessed

Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction

Anu Raghunathan, Jennifer Reed, Sookil Shin, Bernhard Palsson, Simon Daefler BMC Systems Biology 2009, 3:38 (8 April 2009)

Research   Open Access

Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach

Zixiang Xu, Xiao Sun, Shihai Yu BMC Bioinformatics 2009, 10(Suppl 1):S62 (30 January 2009)

Research article   Open Access Highly Accessed

Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii

Nanette R Boyle, John A Morgan BMC Systems Biology 2009, 3:4 (7 January 2009)

Research article   Open Access Highly Accessed

A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory

Juan Nogales, Bernhard Ø Palsson, Ines Thiele BMC Systems Biology 2008, 2:79 (16 September 2008)

Methodology article   Open Access

Exploiting the pathway structure of metabolism to reveal high-order epistasis

Marcin Imielinski, Calin Belta BMC Systems Biology 2008, 2:40 (30 April 2008)

Research   Open Access

Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks

Ádám Kun, Balázs Papp, Eörs Szathmáry Genome Biology 2008, 9:R51 (10 March 2008)

Small-molecular metabolic autocatalytic regulators, which are crucial to metabolic pathways, are identified in a novel systems-wide study in different organisms, revealing that in the enzymatic reactions of conserved autocatalytic cycles, the autocatalytic behavior of replicators varies.

Database   Open Access Highly Accessed

The RAST Server: Rapid Annotations using Subsystems Technology

Ramy K Aziz, Daniela Bartels, Aaron A Best, Matthew DeJongh, Terrence Disz, Robert A Edwards, Kevin Formsma, Svetlana Gerdes, Elizabeth M Glass, Michael Kubal, Folker Meyer, Gary J Olsen, Robert Olson, Andrei L Osterman, Ross A Overbeek, Leslie K McNeil, Daniel Paarmann, Tobias Paczian, Bruce Parrello, Gordon D Pusch, Claudia Reich, Rick Stevens, Olga Vassieva, Veronika Vonstein, Andreas Wilke, Olga Zagnitko BMC Genomics 2008, 9:75 (8 February 2008)

Research article   Open Access

Three factors underlying incorrect in silico predictions of essential metabolic genes

Scott A Becker, Bernhard O Palsson BMC Systems Biology 2008, 2:14 (4 February 2008)

Software   Open Access

Integrated network reconstruction, visualization and analysis using YANAsquare

Roland Schwarz, Chunguang Liang, Christoph Kaleta, Mark Kühnel, Eik Hoffmann, Sergei Kuznetsov, Michael Hecker, Gareth Griffiths, Stefan Schuster, Thomas Dandekar BMC Bioinformatics 2007, 8:313 (28 August 2007)

Research   Open Access Highly Accessed

GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism

Dany JV Beste, Tracy Hooper, Graham Stewart, Bhushan Bonde, Claudio Avignone-Rossa, Michael E Bushell, Paul Wheeler, Steffen Klamt, Andrzej M Kierzek, Johnjoe McFadden Genome Biology 2007, 8:R89 (23 May 2007)

GSMN-TB, a genome-scale metabolic model of M. tuberculosis, was constructed and validated using experimental data.

Research article   Open Access Highly Accessed

Toward the automated generation of genome-scale metabolic networks in the SEED

Matthew DeJongh, Kevin Formsma, Paul Boillot, John Gould, Matthew Rycenga, Aaron Best BMC Bioinformatics 2007, 8:139 (26 April 2007)

Research article   Open Access Highly Accessed

Accelerating the reconstruction of genome-scale metabolic networks

Richard A Notebaart, Frank HJ van Enckevort, Christof Francke, Roland J Siezen, Bas Teusink BMC Bioinformatics 2006, 7:296 (13 June 2006)

Research article   Open Access Highly Accessed

Low degree metabolites explain essential reactions and enhance modularity in biological networks

Areejit Samal, Shalini Singh, Varun Giri, Sandeep Krishna, Nandula Raghuram, Sanjay Jain BMC Bioinformatics 2006, 7:118 (8 March 2006)

Almost all essential metabolic reactions from three microorganisms can be identified because they are the only producer or consumer of a metabolite, and these metabolites act as connections between reactions with strongly correlated fluxes.

Research article   Open Access

Metabolite coupling in genome-scale metabolic networks

Scott A Becker, Nathan D Price, Bernhard Ø Palsson BMC Bioinformatics 2006, 7:111 (6 March 2006)

Research article   Open Access

Algebraic comparison of metabolic networks, phylogenetic inference, and metabolic innovation

Christian V Forst, Christoph Flamm, Ivo L Hofacker, Peter F Stadler BMC Bioinformatics 2006, 7:67 (14 February 2006)