Figure 5.

Preventing abortion by neutralizing IFN-γ. IFN-γ was neutralized in mice by administering anti-mouse IFN-γ monoclonal antibody (clone HB170) in vivo using 1 mg of antibody in a volume of 0.5 ml intraperitoneally 24 h before infection. Control mice were given 1 mg of normal rat IgG in 0.5 ml according to the same injection schedule as the corresponding anti-IFN-γ monoclonal antibody treatment groups. (A) IFN-γ in serum measured by ELISA. The mean and SE for groups of five mice are shown (B) Number of fetuses. Statistically significant differences between the untreated control and antibody treated mice are indicated by asterisks (*, P < 0.01).