Figure 4.

ST6GAL1 siRNA-transduced respiratory cells resisted human influenza virus challenge and did not induce an interferon response. Transduced A549 cells were challenged with H3N2, pdmH1N1, or H9N2 viruses. (A) A reduction in viral yield was seen in ST6GAL1 siRNA-transduced cells infected with and pdmH1N1 (B) H3N2 influenza viruses. aP < 0.05. (C) Viral yield was not affected when cells were infected with the avian H9N2 virus. (D) Treatment with ST6GAL1 siRNAs resulted in a reduced capacity for viral replication during virus entry. aP < 0.05. (E) ELISAs were used to measure levels of IFN-β production following treatment with siRNAs.

Wu et al. BMC Microbiology 2014 14:78   doi:10.1186/1471-2180-14-78
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