Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii
1 Normandie University, Caen, France
2 Laboratory “Polymères, Biopolymères, Surfaces”, UMR 6270 & FR 3038 CNRS, IRIB, University of Rouen, Mont-Saint-Aignan, Cedex 76821, France
3 University of Rouen, Rouen University Hospital, GRAM, Rouen, EA 2656, France
4 Department of Microbiology, Hospital Clinic, Barcelona, Spain
BMC Microbiology 2014, 14:62 doi:10.1186/1471-2180-14-62Published: 12 March 2014
Additional file 1: Figure S1:
Virstatin effect on A. baumannii ATCC 17978 growth in planktonic and biofilm modes. A- Growth curves of A. baumannii in MH broth (☐), MH broth with 0.5% DMSO (volume used for the addition of 100 μM virstatin) (◇), or MH broth with 100 μM virstatin (△). B- A. baumannii colony forming units after a 24 h planktonic (◆) and biofilm (●) growth depending on virstatin concentrations. Curves are given as an average of 3 replicates.
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Additional file 2: Figure S2:
Dispersing effect of virstatin. Virstatin added at 100 μM on 24 h preformed biofilms. Quantification of biofilm biomass was made by crystal violet staining after additional 24 h growth. “*” for P < 0.05.
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Additional file 3: Table S1:
Virstatin effect on A. baumannii clinical isolates.
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